AT-130 (Standard)
AT-130 (Standard) is the analytical standard of AT-130. This product is intended for research and analytical applications. AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an EC50 of 0.13 μM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells[1][2][3].
Product Specifications
CAS Number
211364-06-6
Target
DNA/RNA Synthesis; HBV; Reference Standards
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Field of Research
Cancer; Infection
Smiles
O=C(N/C(C(N1CCCCC1)=O)=C(Br)\C2=CC=CC=C2OC)C3=CC=C([N+]([O-])=O)C=C3
Molecular Formula
C22H22BrN3O5
Molecular Weight
488.33
References & Citations
[1]William E Delaney 4th, et al. Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro. Antimicrob Agents Chemother. 2002 Sep;46 (9) :3057-60.|[2]R B Perni , et al. Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication. Bioorg Med Chem Lett. 2000 Dec 4;10 (23) :2687-90.|[3]J J Feld, et al. The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packaging. Antiviral Res. 2007 Nov;76 (2) :168-77.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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