PQR620 (Standard)
PQR620 (Standard) is the analytical standard of PQR620. This product is intended for research and analytical applications. PQR620 is an orally bioavailable and selective brain penetrant inhibitor of mTORC1/2[1].
Product Specifications
CAS Number
1927857-56-4
Target
MTOR; Reference Standards
Related Pathways
Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
[H][C@]1(CC[C@]([H])2COC1)N2C3=NC(N4[C@]5([H])CC[C@]([H])4COC5)=NC(C6=CN=C(N)C=C6C(F)F)=N3
Molecular Formula
C21H25F2N7O2
Molecular Weight
445.47
References & Citations
[1]Florent Beaufils, et al. Abstract 1336: Structure-activity relationship studies, synthesis, and biological evaluation of PQR620, a highly potent and selective mTORC1/2 inhibitor. Cancer Research; 2016 Apr 16-20.|[2]Chiara Tarantelli, et al. Targeting the PI3K/mTOR Pathway in Lymphoma with PQR309 and PQR620: Single Agent Activity and Synergism with the BCL2 Inhibitor Venetoclax. Blood 2016 128:3017.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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