BAY1125976 (Standard)
BAY1125976 (Standard) is the analytical standard of BAY1125976 (HY-100018) . This product is intended for research and analytical applications. BAY1125976, a chemical probe, is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
Product Specifications
CAS Number
[1402608-02-9]
Target
Akt; Reference Standards
Related Pathways
Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(C1=NN2C(C=C1)=NC(C3=CC=C(C4(N)CCC4)C=C3)=C2C5=CC=CC=C5)N
Molecular Formula
C23H21N5O
Molecular Weight
383.45
References & Citations
[1]Politz O, et al. BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. Int J Cancer. 2017 Jan 15;140 (2) :449-459.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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