KDM5A-IN-1 (Standard)
KDM5A-IN-1 (Standard) is the analytical standard of KDM5A-IN-1 (HY-100014) . This product is intended for research and analytical applications. KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B) [1].
Product Specifications
CAS Number
[1905481-36-8]
Target
Histone Demethylase; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
O=C(C1CC1)N[C@@H]2CCN(C(C3=CC(C(C)C)=NN3)=O)C2
Molecular Formula
C15H22N4O2
Molecular Weight
290.37
References & Citations
[1]Liang J, et al. From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg Med Chem Lett. 2017 Jul 1;27 (13) :2974-2981.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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