SR-3029 (Standard)

SR-3029 (Standard) is the analytical standard of SR-3029 (HY-100011) . This product is intended for research and analytical applications. SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases.

Product Specifications

CAS Number

[1454585-06-8]

Target

Casein Kinase; Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Others; Stem Cell/Wnt

Field of Research

Cancer

Smiles

FC1=CC(N2C=NC3=C(NCC4=NC5=CC=C(F)C(F)=C5N4)N=C(N6CCOCC6)N=C23)=CC=C1

Molecular Formula

C23H19F3N8O

Molecular Weight

480.45

References & Citations

[1]Bibian M, et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23 (15) :4374-80.|[2]Rosenberg LH, et al. Therapeutic targeting of casein kinase 1δ in breast cancer. Sci Transl Med. 2015 Dec 16;7 (318) :318ra202.