MRT68921 (dihydrochloride) (Standard)

MRT68921 (dihydrochloride) (Standard) is the analytical standard of MRT68921 (dihydrochloride) (HY-100006A) . This product is intended for research and analytical applications. MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer[1][2].

Product Specifications

CAS Number

[2080306-21-2]

Target

Apoptosis; Bcl-2 Family; GSK-3; Reactive Oxygen Species (ROS) ; Reference Standards; ULK

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer

Smiles

[H]Cl.O=C(C1CCC1)NCCCNC2=NC(NC3=CC4=C(CN(C)CC4)C=C3)=NC=C2C5CC5.[H]Cl

Molecular Formula

C25H36Cl2N6O

Molecular Weight

507.50

References & Citations

[1]Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR) -dependent autophagy. J Biol Chem. 2015 May 1;290 (18) :11376-83.|[2]Chen Y, et al. Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities. Cell Death Dis. 2020 Sep 1;11 (8) :712.