ML162 (Standard)

ML162 (Standard) is the analytical standard of ML162 (HY-100002) . This product is intended for research and analytical applications. ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines[1][2]

Product Specifications

CAS Number

[1035072-16-2]

Target

Ferroptosis; Glutathione Peroxidase; Reference Standards

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=C(CCl)N(C(C1=CC=CS1)C(NCCC2=CC=CC=C2)=O)C3=CC=C(OC)C(Cl)=C3

Molecular Formula

C23H22Cl2N2O3S

Molecular Weight

477.40

References & Citations

[1]Michel Weïwer, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg Med Chem Lett. 2012 Feb 15;22 (4) :1822-6.|[2]Daiha Shin, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462.