VAV1 degrader-3
VAV1 degrader-3 (Example 185) is an orally active VAV1 molecular glue degrader (DC50: 7 nM) . VAV1 degrader-3 reduces immune cell activation, immune cell proliferation and the production of various cytokines. VAV1 degrader-3 can be used for research of inflammatory or autoimmune disorder. VAV1 degrader-3 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc.[1].
Product Specifications
CAS Number
[3050683-38-7]
UNSPSC
12352101
Target
Molecular Glues
Type
Reference compound
Related Pathways
PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vav1-degrader-3.html
Purity
99.26
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=C(C2CCC(NC2=O)=O)C=CC=C1C3=CC=C(N4C(C=CC=C4)=O)C=C3
Molecular Formula
C22H17ClN2O3
Molecular Weight
392.83
References & Citations
[1]Laura Ann Mcallister, et al. Targeted degradation of vav1. Patent. WO2024151547A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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