MI-136

MI-136 is an inhibitor of the menin-MLL protein-protein interaction (PPI), with an IC50 of 31 nM and a Kd of 23.6 nM. MI-136 shows to block AR signaling and has the potential for the study in castration-resistant tumors[1][2].

Product Specifications

CAS Number

[1628316-74-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Androgen Receptor; Apoptosis; Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MI-136.html

Purity

99.04

Solubility

DMSO : 110 mg/mL (ultrasonic)

Smiles

FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=CC=C(NC(C#N)=C5)C5=C4)CC3

Molecular Formula

C23H21F3N6S

Molecular Weight

470.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Dmitry Borkin, et al. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL) . J Med Chem. 2016 Feb 11;59 (3) :892-913.|[2]Rohit Malik, et al. Targeting the MLL complex in castration-resistant prostate cancer. Nat Med. 2015 Apr;21 (4) :344-52.