GW768505A (free base)
GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1].
Product Specifications
CAS Number
501693-25-0
UNSPSC
12352005
Target
Tie; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gw768505a-free-base.html
Concentration
10mM
Purity
99.26
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C3=C(C4=CC=C(OC)C=C4)OC5=NC=NC(N)=C53)C=C2
Molecular Formula
C27H19F4N5O3
Molecular Weight
537.47
References & Citations
[1]Miyazaki Y, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17 (6) :1773-8.|[2]Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34 (1) :95-103.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Tie2; VEGFR2/KDR/Flk-1
Available Sizes
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