GW768505A (free base)

GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1].

Product Specifications

CAS Number

[501693-25-0]

UNSPSC

12352005

Target

Tie; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gw768505a-free-base.html

Concentration

10mM

Purity

99.26

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C3=C(C4=CC=C(OC)C=C4)OC5=NC=NC(N)=C53)C=C2

Molecular Formula

C27H19F4N5O3

Molecular Weight

537.47

References & Citations

[1]Miyazaki Y, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17 (6) :1773-8.|[2]Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34 (1) :95-103.