SmCB1-IN-1
SmCB1-IN-1 (Compound 2h) is an inhibitor for S. mansoni cathepsin B1 (SmCB1) with an Ki of 0.05 μM[1]. SmCB1-IN-1 exhibits selectivity toward human off-target cathepsins (29% and 37% inhibition for CatB and CatL at 20 μM) . SmCB1-IN-1 inhibits 68% Schistosoma mansoni at 1 μM[1].
Product Specifications
UNSPSC
12352005
Target
Cathepsin; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/smcb1-in-1.html
Smiles
O=S(/C=C/[C@@H](NC(C1=C2C(OCCO2)=CC=C1)=O)CCC3=CC=CC=C3)(OC4=CC=CC=C4)=O
Molecular Formula
C26H25NO6S
Molecular Weight
479.54
References & Citations
[1]Fuchs N, et al., Dual Strategy to Design New Agents Targeting Schistosoma mansoni: Advancing Phenotypic and SmCB1 Inhibitors for Improved Efficacy. ACS Infect Dis. 2024 May 10;10 (5) :1664-1678.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin B; Schistosome
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