Ramos SMAD/TGFbeta Reporter (Luc) stable cell line

Ramos SMAD/TGFbeta Reporter (Luc) cells are derived from the human B lymphocyte cell line Ramos by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. Ramos cell line was generated from a human Burkitt?s lymphoma which does not possess the EBV genome, has been widely used in cancer research, virus study and drug development. Ramos cells express CD19, CD20, and other B-cell markers, making them a useful model for B-cell studies and test the efficacy of monoclonal antibodies and CAR T-cell therapies targeting B-cell malignancies. Ramos SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.