CCRF-CEM/NF-kB Reporter (Luc) stable cell line

CCRF-CEM/NF-kB Reporter (Luc) cells are derived from the human CCRF-CEM T lymphoblast cell line by stably integration of a NF-kB firefly luciferase reporter construct. CCRF-CEM cell line was generated from acute lymphoblastic leukemia, has been widely used for investigating the mechanisms underlying leukemia development, progression, and drug resistance. Additionally, these cells are often employed in screening assays to evaluate the efficacy and toxicity of potential anti-leukemic drugs. CCRF-CEM/NF-kB Reporter (Luc) cells stably express firefly luciferase under the control of the NF-kB response elements, can be used for monitoring the activity of NF-kB signaling pathway.