KCL22-r/RFP-Luciferase stable cell line

KCL22-r/RFP-luciferase cells are derived from human lymphoblast-like cell line KCL22-r by stably integration of a constitutive RFP and Firefly luciferase stably expression construct. KCL22-r cells are a variant of the KCL22 cell line that is specifically used to study resistance to imatinib, a tyrosine kinase inhibitor commonly used to treat chronic myeloid leukemia (CML) . Imatinib targets the BCR-ABL fusion protein, which is a key driver of CML. The paired KCL22-s and KCL22-r clones are useful cell line models of sensitivity and resistance to imatinib. KCL22-r/RFP-luciferase cells stably express RFP and Firefly luciferase, can be used for in vitro assays and in vivo imaging.