HEL 92.1.7 SMAD/TGFbeta Reporter (Luc) stable cell line

HEL 92.1.7 SMAD/TGFbeta Reporter (Luc) cells are derived from the human erythroblast HEL 92.1.7 cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. The HEL 92.1.7 cell line is a valuable tool for understanding the molecular mechanisms underlying chronic myelogenous leukemia (CML) and for testing potential treatment. HEL 92.1.7 SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.