REC-1/NF-kB Reporter (Luc) stable cell line

REC-1/NF-kB Reporter (Luc) cells are derived from the human B-cell lymphoma cell line REC-1 by stably integration of a NF-kB firefly luciferase reporter construct. REC-1 is derived from a patient with mantle cell lymphoma (MCL), making it a valuable model for studying this specific type of lymphoma. REC-1 cells are used to investigate the molecular pathways involved in MCL pathogenesis, including the role of cyclin D1 in cell cycle regulation, as well as to evaluate the efficacy of new therapeutic agents, including chemotherapy and targeted therapies. REC-1/NF-kB Reporter (Luc) cells stably express firefly luciferase under the control of the NF-kB response elements, can be used for monitoring the activity of NF-kB signaling pathway.