DU145/NF-kB Reporter (Luc) stable cell line

DU145/NF-kB Reporter (Luc) cells are derived from the human prostate cancer cell line DU145 by stably integration of a NF-kB firefly luciferase reporter construct. DU145 cells represent an aggressive and androgen-independent form of prostate cancer, which is often resistant to standard hormone-based therapies. DU145 cell line has been used as a model for identifying the molecular mechanisms underlying prostate cancer progression and metastasis, as well as potential therapeutic targets for the treatment of advanced prostate cancer. DU145/NF-kB Reporter (Luc) cells stably express firefly luciferase under the control of the NF-kB response elements, can be used for monitoring the activity of NF-kB signaling pathway.