NALM-1 SMAD/TGFbeta Reporter (Luc) stable cell line

NALM-1 SMAD/TGFbeta Reporter (Luc) cells are derived from the human lymphoblast NALM-1 cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. The NALM-1 cell line is one of five BCR-ABL1 positive cell lines that are resistant to imatinib-induced apoptosis. NALM-1 cell line is widely used in cancer research, particularly in studies focusing on leukemia and the mechanisms of drug resistance. NALM-1 SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.