THP-1/RFP-Luciferase stable cell line

THP-1/RFP-luciferase cells are derived from the human monocytic THP-1 cell line by stably integration of a constitutive RFP-firefly luciferase expression construct. THP-1 cells are undifferentiated monocytes, but they can be induced to differentiate into macrophage-like cells upon treatment with agents such as phorbol 12-myristate 13-acetate (PMA), making them a useful model for studying the differentiation of monocytes into macrophages and their role in immune responses and inflammation. THP-1/RFP-Luciferase cells stably express both RFP and firefly luciferase reporters, can be used for in vitro assays and in vivo imaging.