MM.1R SMAD/TGFbeta Reporter (Luc) stable cell line

MM.1R SMAD/TGFbeta Reporter (Luc) cells are derived from the human B lymphoblast MM.1R cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. MM.1R cells have been used in to study the molecular and cellular mechanisms that drive multiple myeloma progression, and test the efficacy of new drugs or treatment strategies for multiple myeloma. MM.1R and MM.1S, were independently created from the parental cell line MM.1 to represent models of resistance and sensitivity, respectively, to dexamethasone. MM.1R SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.