4T1/NF-kB Reporter (Luc) stable cell line

4T1/NF-kB Reporter (Luc) cells are derived from the mouse mammary carcinoma 4T1 cell line by stably integration of a NF-kB firefly luciferase reporter construct. The 4T1 mammary carcinoma is a transplantable tumor cell line that is highly tumorigenic and invasive and, unlike most tumor models, can spontaneously metastasize from the primary tumor in the mammary gland to multiple distant sites including lymph nodes, blood, liver, lung, brain, and bone. 4T1 cell line has been widely used in cancer research and drug development. 4T1/NF-kB Reporter (Luc) cells stably express firefly luciferase under the control of the NF-kB response elements, can be used for monitoring the activity of NF-kB signaling pathway.