ATDC5 SMAD/TGFbeta Reporter (Luc) stable cell line

ATDC5 SMAD/TGFbeta Reporter (Luc) cells are derived from the mouse teratocarcinoma ATDC5 cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. ATDC5 cell line is characterized as a chondrogenic cell line which goes through a sequential process analogy to chondrocyte differentiation. It is a well established in vitro model of endochondral ossification. ATDC5 SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.