HCC827 SMAD/TGFbeta Reporter (Luc) stable cell line

HCC827 SMAD/TGFbeta Reporter (Luc) cells are derived from the human lung adenocarcinoma HCC827 cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. HCC827 cells are widely used in cancer research, particularly in studies related to lung cancer biology and drug discovery. HCC827 cells carry a mutation in the epidermal growth factor receptor (EGFR) gene, which results in constitutive activation of the EGFR signaling pathway, have been used as a model system to study the mechanisms of EGFR tyrosine kinase inhibitors (TKIs) and to evaluate the efficacy of these drugs in preclinical studies. HCC827 SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used monitoring the activity of TGF?/SMAD signaling pathway.