Raji SMAD/TGFbeta Reporter (Luc) stable cell line

Raji SMAD/TGFbeta Reporter (Luc) cells are derived from the human Raji B lymphoblastoid cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. Raji cell line was generated from human Brukitt's lymphoma. Raji cells express CD19, making them a useful model for studying CD19-related signaling and therapies. Raji cells are used to assess the effectiveness of CAR T cells engineered to target CD19, and serve as a model to test CD19-targeting antibodies for potential therapeutic applications. Raji SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.