CCRF-CEM/STAT3 Reporter (Luc) stable cell line

CCRF-CEM/STAT3 Reporter (Luc) cells are derived from the human CCRF-CEM T lymphoblast cell line by stably integration of a STAT3 firefly luciferase reporter construct. CCRF-CEM cell line was generated from acute lymphoblastic leukemia, has been widely used for investigating the mechanisms underlying leukemia development, progression, and drug resistance. Additionally, these cells are often employed in screening assays to evaluate the efficacy and toxicity of potential anti-leukemic drugs. CCRF-CEM/STAT3 Reporter (Luc) cells stably express firefly luciferase under the control of the STAT3 response elements, can be used for monitoring the activity of STAT3 signaling pathway.