NCI-H358/NF-kB Reporter (Luc) stable cell line

NCI-H358/NF-kB Reporter (Luc) cells are derived from the human non-small cell lung cancer (NSCLC) NCI-H358 cell line by stably integration of a NF-kB firefly luciferase reporter construct. The NCI-H358 cell line is notable for its mutations in the KRAS gene. NCI-H358 cells have been used to study mechanisms of cancer biology, particularly those related to KRAS signaling, as well as to evaluate the efficacy of targeted therapies and novel compounds against KRAS-mutant cancers. NCI-H358/NF-kB Reporter (Luc) cells stably express firefly luciferase under the control of the NF-kB response elements, can be used for monitoring the activity of NF-kB signaling pathway.