4T1 SMAD/TGFbeta Reporter (Luc) stable cell line

4T1 SMAD/TGFbeta Reporter (Luc) cells are derived from the mouse mammary carcinoma 4T1 cell line by stably integration of a SMAD/TGFbeta firefly luciferase reporter construct. The 4T1 mammary carcinoma is a transplantable tumor cell line that is highly tumorigenic and invasive and, unlike most tumor models, can spontaneously metastasize from the primary tumor in the mammary gland to multiple distant sites including lymph nodes, blood, liver, lung, brain, and bone. 4T1 cell line has been widely used in cancer research and drug development. 4T1 SMAD/TGFbeta Reporter (Luc) cells stably express firefly luciferase under the control of the SMAD/TGFbeta response elements, can be used for monitoring the activity of TGF?/SMAD signaling pathway.