CCRF-CEM/STAT5 Reporter (Luc) stable cell line

CCRF-CEM/STAT5 Reporter (Luc) cells are derived from the human CCRF-CEM T lymphoblast cell line by stably integration of a STAT5 firefly luciferase reporter construct. CCRF-CEM cell line was generated from acute lymphoblastic leukemia, has been widely used for investigating the mechanisms underlying leukemia development, progression, and drug resistance. Additionally, these cells are often employed in screening assays to evaluate the efficacy and toxicity of potential anti-leukemic drugs. CCRF-CEM/STAT5 Reporter (Luc) cells stably express firefly luciferase under the control of the STAT5 response elements, can be used for monitoring the activity of STAT5 signaling pathway.