Endoxifen (E-isomer hydrochloride)

Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects[1][2].

Product Specifications

CAS Number

[1197194-61-8]

Product Name Alternative

E-Endoxifen hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Endoxifen-E-isomer-hydrochloride.html

Purity

98.20

Solubility

DMSO : ≥ 30 mg/mL

Smiles

OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1.[H]Cl

Molecular Formula

C25H28ClNO2

Molecular Weight

409.95

Precautions

H302, H315, H319

References & Citations

[1]Elkins P, et, al. Characterization of the isomeric configuration and impurities of (Z) -endoxifen by 2D NMR, high resolution LC⬜MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.|[2]Zheng Y, et, al. Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. Drug Metab Dispos. 2007 Oct;35 (10) :1942-8.