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Apcin-A (monohydrochloride)

Apcin-A monohydrochloride, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A monohydrochloride interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A monohydrochloride can be used to synthesize the PROTAC CP5V.

Product Specifications

CAS Number

1683535-53-6

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

APC; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apcin-a-monohydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(NC(C(Cl)(Cl)Cl)NC1=NC=CC=N1)OCCCN.Cl

Molecular Formula

C10H15Cl4N5O2

Molecular Weight

379.07

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1] Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964 (19) 30677-2.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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