Adriforant (hydrochloride)
Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (Ki=2.4 nM) and is also a functional (Ki=1.56 nM) antagonist.
Product Specifications
CAS Number
[2096455-90-0]
Product Name Alternative
PF-3893787 (hydrochloride)
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/PF-3893787_hydrochloride.html
Purity
98.0
Solubility
DMSO : ≥ 83.33 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
NC1=NC(N2C[C@H](NC)CC2)=CC(NCC3CC3)=N1.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C13H25Cl3N6
Molecular Weight
371.74
References & Citations
[1]Mowbray CE, et al. Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov 1;21 (21) :6596-602.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
H4 Receptor
Available Sizes
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