Adriforant (hydrochloride)

Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist binding affinity (Ki=2.4 nM) and is also a functional (Ki=1.56 nM) antagonist.

Product Specifications

CAS Number

[2096455-90-0]

Product Name Alternative

PF-3893787 (hydrochloride)

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/PF-3893787_hydrochloride.html

Purity

98.0

Solubility

DMSO : ≥ 83.33 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

NC1=NC(N2C[C@H](NC)CC2)=CC(NCC3CC3)=N1.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C13H25Cl3N6

Molecular Weight

371.74

References & Citations

[1]Mowbray CE, et al. Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov 1;21 (21) :6596-602.