ω-Conotoxin SO3

ω-Conotoxin SO3 is a blocker of N-type voltage-sensitive calcium channel. ω-Conotoxin SO3 is an analgesicω-conotoxin that can be isolated from the venom of C. striatus[1][2].

O=C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](C)C(NCC(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(N[C@H]2CCCCN)=O)=O)=O)=O)NC3=O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CC(N)=O)C(N[C@H]5CSSC[C@@H](C(N)=O)NC2=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(N[C@@H]([C@H](O)C)C(NCC(N[C@H]3CO)=O)=O)=O)NC5=O)N

[1]Wen L, et al, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons. Br J Pharmacol. 2005 Jul;145(6):728-39.|[2]Yan LD, et al. Spinal antinociception of synthetic omega-conotoxin SO-3, a selective N-type neuronal voltage-sensitive calcium channel blocker, and its effects on morphine analgesia in chemical stimulus tests in rodent. Eur J Pharmacol. 2010 Jun 25;636(1-3):73-81.