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JX237

JX237 is an inhibitor of the epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 value of 31 nM. SLC6A19 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B0AT1, JX237 can be used for the study of disorders of amino acid metabolism[1].

Product Specifications

CAS Number

1021125-90-5

UNSPSC

12352211

Target

Amino acid Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/jx237.html

Purity

98.84

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

BrC1=C(C)C=C(NCC(NCC)=O)C=C1

Molecular Formula

C11H15BrN2O

Molecular Weight

271.15

References & Citations

[1]Xu J, et al. Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19) . Nat Commun. 2024 Aug 22;15 (1) :7224.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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