JX237
JX237 is an inhibitor of the epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 value of 31 nM. SLC6A19 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B0AT1, JX237 can be used for the study of disorders of amino acid metabolism[1].
Product Specifications
CAS Number
1021125-90-5
UNSPSC
12352211
Target
Amino acid Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/jx237.html
Purity
98.84
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
BrC1=C(C)C=C(NCC(NCC)=O)C=C1
Molecular Formula
C11H15BrN2O
Molecular Weight
271.15
References & Citations
[1]Xu J, et al. Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19) . Nat Commun. 2024 Aug 22;15 (1) :7224.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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