NOTA-FAPI
NOTA-FAPI is a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI can be used as a probe for FAP-targeted tumour imaging. NOTA-FAPI has good tumour detection efficacy and excellent imaging quality[1][2][3].
Product Specifications
CAS Number
2374782-03-1
UNSPSC
12352005
Target
FAP; Radionuclide-Drug Conjugates (RDCs)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nota-fapi.html
Purity
99.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=NC(C=C2)=C1C=C2OCCCN(CC3)CCN3C(CN(CCN4CC(O)=O)CCN(CC4)CC(O)=O)=O)NCC(N(CC5(F)F)[C@@H](C5)C#N)=O
Molecular Formula
C36H47F2N9O8
Molecular Weight
771.81
References & Citations
[1]Wang S, et al. Clinical translational evaluation of Al18F-NOTA-FAPI for fibroblast activation protein-targeted tumour imaging. Eur J Nucl Med Mol Imaging. 2021 Dec;48 (13) :4259-4271. |[2]Guo YH, et al. Comparison of 18F-AlF-NOTA-FAPI and 18F-FDG Imaging in a Patient With Gastric Signet-Ring Cell Carcinoma. Clin Nucl Med. 2021 Nov 1;46 (11) :929-930.|[3]Ge L, et al. Preclinical evaluation and pilot clinical study of [18F]AlF-NOTA-FAPI-04 for PET imaging of rheumatoid arthritis. Eur J Nucl Med Mol Imaging. 2022 Oct;49 (12) :4025-4036.|[4]Guo YH, et al. Comparison of 18F-AlF-NOTA-FAPI and 18F-FDG Imaging in a Patient With Gastric Signet-Ring Cell Carcinoma. Clin Nucl Med. 2021 Nov 1;46 (11) :929-930.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RDC Bifunctional Chelator
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNUM2368-50 1x 50 µL
Cytokeratin 6A (KRT6A) (Basal Cell Marker) (KRT6A/2368), 1mg/mL
Sign In for Pricing
View Details 
AP02197SU-N 100 µL
Prothymosin, alpha (PTMA) (103-111) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details 
BNC403079-100 1x 100 µL
HER-2 / c-erbB-2 / neu / CD340 (ERBB2/3079), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details