MS170

MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively[1].

Product Specifications

CAS Number

[2376136-61-5]

UNSPSC

12352005

Target

Akt; PROTACs

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms170.html

Purity

98.68

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C2=C(NCCCCCCCCNC(CCNC[C@H](C3=CC=C(C=C3)Cl)C(N4CCN(C5=C6C([C@@H](C[C@H]6C)O)=NC=N5)CC4)=O)=O)C=CC=C2C(N1C7C(NC(CC7)=O)=O)=O

Molecular Formula

C45H56ClN9O7

Molecular Weight

870.44

References & Citations

[1]Yu X, et al. Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders. J Med Chem. 2021;64 (24) :18054-18081.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Akt1; Akt2; Akt3; Cereblon

Available Sizes

Curated Selection

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