Dyrk1A-IN-5
Dyrk1A-IN-5 (Compound 5j) is a potent and selective DYRK1A inhibitor, with an IC50 of 6 nM. yrk1A-IN-5 exhibits significant selectivity for DYRK1B (IC50 = 600 nM) and CLK1 (IC50 = 500 nM), but shows almost no inhibition of DYRK2 (IC50 > 10 μM) . Dyrk1A-IN-5 can be used for Down syndrome research[1].
Product Specifications
CAS Number
[1685235-41-9]
UNSPSC
12352005
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dyrk1a-in-5.html
Purity
98.06
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC2=CC=CC=C2C3=C1C4=C(N3)C(I)=CC=C4)O
Molecular Formula
C16H9IN2O2
Molecular Weight
388.16
References & Citations
[1]Falke H, et al. 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem. 2015 Apr 9;58 (7) :3131-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1; DYRK2
Available Sizes
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