SMS2-IN-2
SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1].
Product Specifications
CAS Number
2241838-28-6
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/SMS2-IN-2.html
Purity
98.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC(C=CC(F)=C1)=C1COC2=CC=CC3=C2C(NC4=CC=CN=C4)=NO3
Molecular Formula
C19H13ClFN3O2
Molecular Weight
369.78
References & Citations
[1]Mo M, et al. Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J Med Chem. 2018 Sep 27;61 (18) :8241-8254.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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