Dextran sulfate sodium salt (MW 35000-45000)

Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a polymer of dehydrated glucose with a molecular weight of approximately 35000-45000. DSS with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a potent inducer of colitis. Dextran sulfate sodium salt (DSS) (MW 35000-45000) can be used to induce model acute colitis, chronic colitis, and colitis-related colon cancer. Dextran sulfate sodium salt (DSS) (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium[1][2][3][4][5].

Product Specifications

CAS Number

[9011-18-1]

Product Name Alternative

DSS (MW 35000-45000) ; DXS (MW 35000-45000)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dextran-sulfate-sodium-salt-mw-35000-50000.html

Purity

0.00

Solubility

H2O : ≥ 100 mg/mL

Smiles

[Dextransulfatesodiumsalt(MW35000-45000)]

Molecular Weight

35000-45000

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee KC, et al. Using Dextran-encapsulated gold nanoparticles as insulin carriers to prolong insulin activity. Nanomedicine (Lond) . 2017 Aug;12 (15) :1823-1834.|[2]Shen B, et al. Dextran Sulfate Sodium Salt-Induced Colitis Aggravates Gut Microbiota Dysbiosis and Liver Injury in Mice With Non-alcoholic Steatohepatitis. Front Microbiol. 2021 Nov 2;12:756299.|[3]Li H, et al. Rabdosia serra alleviates dextran sulfate sodium salt-induced colitis in mice through anti-inflammation, regulating Th17/Treg balance, maintaining intestinal barrier integrity, and modulating gut microbiota. J Pharm Anal. 2022 Dec;12 (6) :824-838.|[4]Whittem CG, et al. Murine Colitis modeling using Dextran Sulfate Sodium (DSS) . J Vis Exp. 2010 Jan 19; (35) :1652.|[5]Martin JC, et al. Dextran Sulfate Sodium (DSS) -Induced Acute Colitis in the Rat. Methods Mol Biol. 2016;1371:197-203.|[6]Kinchen J, et al. Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease. Cell. 2018 Oct 4;175 (2) :372-386.e17.|[7]Zhang H, et al. Biochanin a ameliorates DSS-induced ulcerative colitis by improving colonic barrier function and protects against the development of spontaneous colitis in the Muc2 deficient mice. Chem Biol Interact. 2024 May 25;395:111014.|[8]Dokoshi T, et al. Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice. Nat Commun. 2024 Apr 8;15 (1) :3009.|[9]Wirtz S, et al. Chemically induced mouse models of intestinal inflammation. Nat Protoc. 2007;2 (3) :541-6.|[10]Zhu H, et al. RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer. J Exp Clin Cancer Res. 2017 Jan 5;36 (1) :2.