Tubulin/JAK2-IN-1
Tubulin/JAK2-IN-1 (compound 7g) is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative activity against the cancer cells[1].
Product Specifications
CAS Number
2933938-46-4
UNSPSC
12352005
Target
JAK; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-jak2-in-1.html
Purity
99.14
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C(OC)=CC(C2=NC=CC3=NC(NC4=CC=CC5=C4C=CN5)=NN23)=C1
Molecular Formula
C22H20N6O3
Molecular Weight
416.43
References & Citations
[1]Li Chen, et al. Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2. J Med Chem. 2023.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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