Tubulin/JAK2-IN-1

Tubulin/JAK2-IN-1 (compound 7g) is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative activity against the cancer cells[1].

Product Specifications

CAS Number

[2933938-46-4]

UNSPSC

12352005

Target

JAK; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-jak2-in-1.html

Purity

99.14

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C(OC)=CC(C2=NC=CC3=NC(NC4=CC=CC5=C4C=CN5)=NN23)=C1

Molecular Formula

C22H20N6O3

Molecular Weight

416.43

References & Citations

[1]Li Chen, et al. Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2. J Med Chem. 2023.