β-D-glucuronide-pNP-carbonate
β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[894095-98-8]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/β-d-glucuronide-pnp-carbonate.html
Purity
99.60
Solubility
DMSO : 133.33 mg/mL (ultrasonic)
Smiles
O=C(NCCC(NC(C=C1COC(OC(C=C2)=CC=C2[N+]([O-])=O)=O)=C(C=C1)O[C@H](O[C@@H]3C(OC)=O)[C@@H]([C@H]([C@@H]3OC(C)=O)OC(C)=O)OC(C)=O)=O)OCC4C5=CC=CC=C5C6=CC=CC=C46
Molecular Formula
C45H43N3O18
Molecular Weight
913.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Glycosidase Cleavable Linker
Available Sizes
Curated Selection
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