NIC3
NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity[1].
Product Specifications
CAS Number
[494830-67-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
BTB/POZ Family
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nic3.html
Purity
99.80
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)(C)C1=CC=C(OCC(NCCNC(COC2=CC=C(C(C)(C)C)C=C2)=O)=O)C=C1
Molecular Formula
C26H36N2O4
Molecular Weight
440.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang X, et al. Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents. J Biol Chem. 2019 May 17. pii: jbc.RA119.007664.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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