Elgodipine

Elgodipine (IQB-875 free base) is an orally active dihydropyridine calcium antagonist and an antianginal compound. Elgodipine inhibits both T- and L-type calcium channels (IC50: 32 and 2.3 nM) . Elgodipine lowers systemic vascular resistance and improves systolic cardiac function[1][2][3].

Product Specifications

CAS Number

[119413-55-7]

Product Name Alternative

IQB-875 (free base)

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/elgodipine.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)NC(C)=C(C(OC(C)C)=O)C1C2=C3OCOC3=CC=C2)OCCN(CC4=CC=C(F)C=C4)C

Molecular Formula

C29H33FN2O6

Molecular Weight

524.58

References & Citations

[1]Kuhn A, et al. Hemodynamic and antiischemic effects of intravenous elgodipine, a new dihydropyridine calcium channel blocker, in patients with chronic stable angina. Cardiovasc Drugs Ther. 1995 Aug;9 (4) :595-600. |[2]Lepretre N, et al. Electrophysiological and radioligand binding studies of elgodipine and derivatives in portal vein myocytes. J Pharmacol Exp Ther. 1994 Dec;271 (3) :1209-15. |[3]Acharya DU, et al. Anti-ischaemic and haemodynamic effects of elgodipine, a potent new generation calcium antagonist, in chronic stable angina. Eur Heart J. 1994 May;15 (5) :665-71.