N-Formyldemecolcine

N-Formyldemecolcine is a colchicine precursor that contains the characteristic tropolone ring and pharmacophore of colchicine. N-Formyldemecolcine can be synthesized de novo by genetically engineering transgenic Nicotiana benthamiana and atypical cytochrome P450s that catalyze the production of colchicine's unique carbon scaffold[1].

Product Specifications

CAS Number

[14686-61-4]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-formyldemecolcine.html

Smiles

COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)N(C)C=O)=C3)=CC=C(OC)C3=O

Molecular Formula

C22H25NO6

Molecular Weight

399.44

References & Citations

[1]Nett RS, et al. Discovery and engineering of colchicine alkaloid biosynthesis. Nature. 2020 Aug;584 (7819) :148-153.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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