N-Formyldemecolcine
N-Formyldemecolcine is a colchicine precursor that contains the characteristic tropolone ring and pharmacophore of colchicine. N-Formyldemecolcine can be synthesized de novo by genetically engineering transgenic Nicotiana benthamiana and atypical cytochrome P450s that catalyze the production of colchicine's unique carbon scaffold[1].
Product Specifications
CAS Number
[14686-61-4]
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/n-formyldemecolcine.html
Smiles
COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)N(C)C=O)=C3)=CC=C(OC)C3=O
Molecular Formula
C22H25NO6
Molecular Weight
399.44
References & Citations
[1]Nett RS, et al. Discovery and engineering of colchicine alkaloid biosynthesis. Nature. 2020 Aug;584 (7819) :148-153.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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