Exatecan-amide-bicyclo[1.1.1]pentan-1-ol
Exatecan-amide-bicyclo[1.1.1]pentan-1-ol (Compound 79) is an exatecan derivative that can be used as a payload in drug conjugates. Exatecan-amide-bicyclo[1.1.1]pentan-1-ol has significant inhibitory activity against a variety of tumor cell lines[1].
Product Specifications
CAS Number
2866299-06-9
UNSPSC
12352203
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-amide-bicyclo-1-1-1-pentan-1-ol.html
Solubility
10 mM in DMSO
Smiles
O=C(C12CC(C1)(C2)O)N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84
Molecular Formula
C30H28FN3O6
Molecular Weight
545.56
References & Citations
[1]VRLJIC M, et al. Exatecan derivatives and antibody-drug conjugates thereof. WO2022236136A1. 2022-11-10.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Camptothecins
Frequently Asked Questions
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