Exatecan-amide-bicyclo[1.1.1]pentan-1-ol
Product Specifications
UNSPSC Description
Exatecan-amide-bicyclo[1.1.1]pentan-1-ol (Compound 79) is an exatecan (HY-13631) derivative that can be used as a payload in drug conjugates. Exatecan-amide-bicyclo[1.1.1]pentan-1-ol has significant inhibitory activity against a variety of tumor cell lines[1].
Target Antigen
ADC Cytotoxin; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-amide-bicyclo-1-1-1-pentan-1-ol.html
Solubility
10 mM in DMSO
Smiles
O=C(C12CC(C1)(C2)O)N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84
Molecular Weight
545.56
References & Citations
[1]VRLJIC M, et al. Exatecan derivatives and antibody-drug conjugates thereof. WO2022236136A1. 2022-11-10.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160597/Exatecan-amide-bicyclo-1-1-1-pentan-1-ol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160597/
Clinical Information
No Development Reported
CAS Number
2866299-06-9
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
abx322873-01 50 µg
Activating Transcription Factor 4 Phospho-Ser245 (ATF4 pS245) Antibody
Ask
View Details abx322873-02 100 µg
Activating Transcription Factor 4 Phospho-Ser245 (ATF4 pS245) Antibody
Ask
View Details NBP2-59315AF700 100 µL
Mouse Monoclonal Ankyrin 1 Antibody (S388A-10) [Alexa Fluor 700]
Ask
View Details