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PKR activator 3

PKR activator 3 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR activator 3 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia[1].

Product Specifications

CAS Number

1628428-01-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Pyruvate Kinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pkr-activator-3.html

Purity

99.82

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N1C2C(=C(S(NC3=CC=C(C(N4CCC(O)(CC(C)C)CC4)=O)C=C3)(=O)=O)C=CC=2)N=CC=1

Molecular Formula

C24H28N4O4S

Molecular Weight

468.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Popovici-Muller, et al. Preparation of N- (piperidinecarbonylphenyl) sulfonamide compounds as pyruvate kinase modulators. From PCT Int. Appl. (2014), WO2014139144A1 20140918.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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