DAPTA

DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities.

Product Specifications

CAS Number

[106362-34-9]

Product Name Alternative

D-Ala-peptide T-amide; Adaptavir

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

CCR; HIV

Type

Peptides

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection; Endocrinology

Assay Protocol

https://www.medchemexpress.com/DAPTA.html

Purity

98.87

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](C)N)=O)CO)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)CC(N)=O)=O)C(N[C@@H]([C@@H](C)O)C(N)=O)=O)C=C1

Molecular Formula

C35H56N10O15

Molecular Weight

856.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Pollicita M, et al. Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells. Antivir Chem Chemother. 2007;18 (5) :285-95.|[2]Polianova MT, et al. Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA) . Antiviral Res. 2005 Aug;67 (2) :83-92.